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- B01d4320b9fb60b88ecb16eb0d8085db9 NCIT_P378 "NCI" @default.
- B01d4320b9fb60b88ecb16eb0d8085db9 type Axiom @default.
- B01d4320b9fb60b88ecb16eb0d8085db9 annotatedProperty IAO_0000115 @default.
- B01d4320b9fb60b88ecb16eb0d8085db9 annotatedSource NCIT_C1607 @default.
- B01d4320b9fb60b88ecb16eb0d8085db9 annotatedTarget "A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04)" @default.