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- B029bf9ce4b25434a75a4b5fd372bd38a NCIT_P378 "NCI" @default.
- B029bf9ce4b25434a75a4b5fd372bd38a type Axiom @default.
- B029bf9ce4b25434a75a4b5fd372bd38a annotatedProperty IAO_0000115 @default.
- B029bf9ce4b25434a75a4b5fd372bd38a annotatedSource NCIT_C238 @default.
- B029bf9ce4b25434a75a4b5fd372bd38a annotatedTarget "A polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells." @default.