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- B02b4c0793ebafddec43db3edb3797b94 NCIT_P378 "NCI" @default.
- B02b4c0793ebafddec43db3edb3797b94 type Axiom @default.
- B02b4c0793ebafddec43db3edb3797b94 annotatedProperty IAO_0000115 @default.
- B02b4c0793ebafddec43db3edb3797b94 annotatedSource NCIT_C101255 @default.
- B02b4c0793ebafddec43db3edb3797b94 annotatedTarget "A class of agents that act by selectively inhibiting aldosterone receptor activation with diuretic activity. Aldosterone receptor antagonists bind to and block the activation of aldosterone (mineralocorticoid) receptors on the epithelial cells in the late distal tubule and collecting duct of the kidney, thus preventing the synthesis of aldosterone-induced proteins which enhance Na+ retention and K+ and H+ secretion. The enhanced excretion of Na+ produces diuresis ultimately resulting in a reduction in blood pressure without the loss of K+." @default.