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- B02ba60b94430c977d9a2e6dfcf1171e7 NCIT_P378 "NCI" @default.
- B02ba60b94430c977d9a2e6dfcf1171e7 type Axiom @default.
- B02ba60b94430c977d9a2e6dfcf1171e7 annotatedProperty IAO_0000115 @default.
- B02ba60b94430c977d9a2e6dfcf1171e7 annotatedSource NCIT_C71467 @default.
- B02ba60b94430c977d9a2e6dfcf1171e7 annotatedTarget "A derivative of 4,5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Luminespib has been shown to bind with high affinity to and inhibit Hsp90, resulting in the proteasomal degradation of oncogenic client proteins; the inhibition of cell proliferation; and the elevation of heat shock protein 72 (Hsp72) in a wide range of human tumor cell lines. Hsp90, a 90 kDa molecular chaperone, plays a key role in the conformational maturation, stability and function of other substrate or "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition." @default.