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- B02efa53b6a7799d49af3196de5a305ef NCIT_P378 "NCI" @default.
- B02efa53b6a7799d49af3196de5a305ef type Axiom @default.
- B02efa53b6a7799d49af3196de5a305ef annotatedProperty IAO_0000115 @default.
- B02efa53b6a7799d49af3196de5a305ef annotatedSource NCIT_C29265 @default.
- B02efa53b6a7799d49af3196de5a305ef annotatedTarget "A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors." @default.