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- B034a708d614150c491c59e4ebfb8da35 NCIT_P378 "NCI" @default.
- B034a708d614150c491c59e4ebfb8da35 type Axiom @default.
- B034a708d614150c491c59e4ebfb8da35 annotatedProperty IAO_0000115 @default.
- B034a708d614150c491c59e4ebfb8da35 annotatedSource NCIT_C61874 @default.
- B034a708d614150c491c59e4ebfb8da35 annotatedTarget "A carbazole derivative and a selective serotonin receptor antagonist with antiemetic activity. Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting. The CTZ is located in the area postrema on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle and outside the blood-brain barrier (BBB)." @default.