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- B035224b684cf37fc77594548bed6940d NCIT_P378 "NCI" @default.
- B035224b684cf37fc77594548bed6940d type Axiom @default.
- B035224b684cf37fc77594548bed6940d annotatedProperty IAO_0000115 @default.
- B035224b684cf37fc77594548bed6940d annotatedSource NCIT_C95701 @default.
- B035224b684cf37fc77594548bed6940d annotatedTarget "An orally available cyclin-dependent kinase (CDK) inhibitor targets at cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Ribociclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation." @default.