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- B03aafb976e8ad2522d7c5e005b01a2a0 NCIT_P378 "NCI" @default.
- B03aafb976e8ad2522d7c5e005b01a2a0 type Axiom @default.
- B03aafb976e8ad2522d7c5e005b01a2a0 annotatedProperty IAO_0000115 @default.
- B03aafb976e8ad2522d7c5e005b01a2a0 annotatedSource NCIT_C61764 @default.
- B03aafb976e8ad2522d7c5e005b01a2a0 annotatedTarget "A second generation, long-lasting selective histamine H1 receptor antagonist with antiinflammatory property. Fexofenadine is a highly selective and reversible competitor at peripheral H1 histamine receptors in the gastrointestinal (GI) tract, blood vessels, and bronchial smooth muscle. This agent interferes with mediators release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition fexofenadine may also inhibit the late-phase allergic reaction by acting on leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Overall, this agent blocks the actions of endogenous histamine, thereby leads to temporary relief of the negative symptoms associated with histamine and achieve effects such as decreased vascular permeability, reduction of pruritus and localized smooth muscle relaxation." @default.