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- B03e7515cad7e786ee6ca7f1201615abe NCIT_P378 "NCI" @default.
- B03e7515cad7e786ee6ca7f1201615abe type Axiom @default.
- B03e7515cad7e786ee6ca7f1201615abe annotatedProperty IAO_0000115 @default.
- B03e7515cad7e786ee6ca7f1201615abe annotatedSource NCIT_C113295 @default.
- B03e7515cad7e786ee6ca7f1201615abe annotatedTarget "A covalent conjugate of recombinant human interleukin-10 (IL-10) and polyethylene glycol (PEG), with potential anti-fibrotic, anti-inflammatory, immunomodulating and antineoplastic activities. Upon subcutaneous administration, pegilodecakin may activate cell-mediated immunity against cancer cells by stimulating the differentiation and expansion of tumor specific cytotoxic CD8+ T cells. This agent may also lower serum cholesterol levels and reduce atherosclerotic plaques by inhibiting the synthesis of pro-inflammatory cytokines, such as Interferon-gamma, IL-2, IL-3, TNF-alpha, and GM-CSF. The PEG moiety inhibits proteolytic breakdown and clearance of AM0010, which prolongs its half-life, extends the duration of its therapeutic effects and allows less frequent dosing." @default.