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- B041d6414f2d4d6a630d4e96f359afd0c NCIT_P378 "NCI" @default.
- B041d6414f2d4d6a630d4e96f359afd0c type Axiom @default.
- B041d6414f2d4d6a630d4e96f359afd0c annotatedProperty IAO_0000115 @default.
- B041d6414f2d4d6a630d4e96f359afd0c annotatedSource NCIT_C97507 @default.
- B041d6414f2d4d6a630d4e96f359afd0c annotatedTarget "An orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF-04136309 specifically binds to CCR2 and prevents binding of the endothelium-derived chemokine ligand CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2 activation and signal transduction. This may inhibit inflammatory processes as well as angiogenesis, tumor cell migration, and tumor cell proliferation. The G-protein coupled receptor CCR2 is expressed on the surface of monocytes and macrophages, stimulates the migration and infiltration of these cell types, and plays an important role in inflammation, angiogenesis, and tumor cell migration and proliferation." @default.