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- B042f426797132231a643bde154a06c91 NCIT_P378 "NCI" @default.
- B042f426797132231a643bde154a06c91 type Axiom @default.
- B042f426797132231a643bde154a06c91 annotatedProperty IAO_0000115 @default.
- B042f426797132231a643bde154a06c91 annotatedSource NCIT_C186665 @default.
- B042f426797132231a643bde154a06c91 annotatedTarget "A preparation of allogeneic natural killer cells (NKs) expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) oncofetal trophoblast glycoprotein (5T4; TPBG; Wnt-activated inhibitory factor 1 or WAIF1), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-5T4 CAR-NK cells recognize, bind to and induce selective cytotoxicity in 5T4-expressing tumor cells. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types; its expression is correlated with increased invasiveness." @default.