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- B051cd12870ceddeec6e4b1e8593d817c NCIT_P378 "NCI" @default.
- B051cd12870ceddeec6e4b1e8593d817c type Axiom @default.
- B051cd12870ceddeec6e4b1e8593d817c annotatedProperty IAO_0000115 @default.
- B051cd12870ceddeec6e4b1e8593d817c annotatedSource NCIT_C537 @default.
- B051cd12870ceddeec6e4b1e8593d817c annotatedTarget "A phenylbutylpiperadine derivative with antipsychotic, neuroleptic, and antiemetic activities. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the mesolimbic system of the brain, thereby eliminating dopamine neurotransmission and leading to antidelusionary and antihallucinagenic effects. Antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) accounts for its antiemetic activity." @default.