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- B05c5cbbe2726c989c4ca23f1bbd17919 NCIT_P378 "NCI" @default.
- B05c5cbbe2726c989c4ca23f1bbd17919 type Axiom @default.
- B05c5cbbe2726c989c4ca23f1bbd17919 annotatedProperty IAO_0000115 @default.
- B05c5cbbe2726c989c4ca23f1bbd17919 annotatedSource NCIT_C169053 @default.
- B05c5cbbe2726c989c4ca23f1bbd17919 annotatedTarget "A bispecific antibody that targets both the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and the CD3 antigen found on T-lymphocytes, with potential immunostimulatory and antineoplastic activities. Upon administration of anti-PSMA/CD3 bispecific antibody CCW702, this bispecific antibody binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This activates and redirects CTLs to PSMA-expressing tumor cells, which results in the CTL-mediated cell death of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells." @default.