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- B0683d71c19e926e0e7a3d73b509aad5f NCIT_P378 "NCI" @default.
- B0683d71c19e926e0e7a3d73b509aad5f type Axiom @default.
- B0683d71c19e926e0e7a3d73b509aad5f annotatedProperty IAO_0000115 @default.
- B0683d71c19e926e0e7a3d73b509aad5f annotatedSource NCIT_C62025 @default.
- B0683d71c19e926e0e7a3d73b509aad5f annotatedTarget "A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output." @default.