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- B0715ec6796cd9aac1c733a6efd60ae3f NCIT_P378 "NCI" @default.
- B0715ec6796cd9aac1c733a6efd60ae3f type Axiom @default.
- B0715ec6796cd9aac1c733a6efd60ae3f annotatedProperty IAO_0000115 @default.
- B0715ec6796cd9aac1c733a6efd60ae3f annotatedSource NCIT_C153118 @default.
- B0715ec6796cd9aac1c733a6efd60ae3f annotatedTarget "A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19, coupled to the costimulatory domains of 4-1BB (CD137) and the zeta chain of the human T-cell receptor (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells PZ01 target, bind to, and induce selective toxicity in CD19-expressing B cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies." @default.