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- B07b4cc2db9c9268b470627858cee146a NCIT_P378 "NCI" @default.
- B07b4cc2db9c9268b470627858cee146a type Axiom @default.
- B07b4cc2db9c9268b470627858cee146a annotatedProperty IAO_0000115 @default.
- B07b4cc2db9c9268b470627858cee146a annotatedSource NCIT_C192005 @default.
- B07b4cc2db9c9268b470627858cee146a annotatedTarget "An orally bioavailable, mutant-selective, fourth-generation epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, EGFR mutant-selective inhibitor QLH11811 targets, binds to and inhibits the activity of EGFR with selective mutations, including ex19del, L858R, T790M and C797S, thereby preventing EGFR mutant-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR mutant-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.