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- B08bb55faeb2c7b26717c54df8dbdae8b NCIT_P378 "NCI" @default.
- B08bb55faeb2c7b26717c54df8dbdae8b type Axiom @default.
- B08bb55faeb2c7b26717c54df8dbdae8b annotatedProperty IAO_0000115 @default.
- B08bb55faeb2c7b26717c54df8dbdae8b annotatedSource NCIT_C119620 @default.
- B08bb55faeb2c7b26717c54df8dbdae8b annotatedTarget "A bispecific monoclonal antibody directed against both the Notch ligand delta-like 4 (DLL4) and the human tyrosine kinase vascular endothelial growth factor (VEGF), with potential anti-angiogenic and antineoplastic activities. The anti-DLL4 moiety of navicixizumab specifically binds to DLL4, prevents its interaction with Notch receptors, and inhibits Notch-mediated signaling and gene transcription, which may both block tumor angiogenesis and inhibit tumor cell growth. The anti-VEGF moiety binds to VEGF and prevents the binding of VEGF to its receptor, which blocks VEGF-mediated signaling and further inhibits the growth and maintenance of tumor blood vessels. The expression of DLL4 is highly restricted to the vascular endothelium; DLL4/Notch signaling is required for the development of functional tumor blood vessels. The expression of the pro-angiogenic growth factor VEGF is associated with tumor angiogenesis and tumor cell proliferation and invasion." @default.