Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B08e8dcb49eea5b66bc92e3af5d412f21> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B08e8dcb49eea5b66bc92e3af5d412f21 NCIT_P378 "NCI" @default.
- B08e8dcb49eea5b66bc92e3af5d412f21 type Axiom @default.
- B08e8dcb49eea5b66bc92e3af5d412f21 annotatedProperty IAO_0000115 @default.
- B08e8dcb49eea5b66bc92e3af5d412f21 annotatedSource NCIT_C60769 @default.
- B08e8dcb49eea5b66bc92e3af5d412f21 annotatedTarget "A sesquiterpene lactone peroxide and dimerized plant product derived from Artemisia annua L with anti-malarial, anti-proliferative and anti-angiogenic effects. Artemisinin contains an endoperoxide moiety which forms free radicals when it reacts with iron. The resultant carbon-based radical can lead to cellular damage and cell death by reacting with cellular macromolecules such as proteins and membrane lipids. Malaria parasites contain large amounts of heme-iron, a product from the digestion of hemoglobin. However, recently it has been suggested that activation of artemisinin inside the parasite is by ferrous iron. Furthermore, due to their rapid rate of division, cancer cells require and uptake a large amount of iron to proliferate, therefore they are more susceptible to the cytotoxic effect of artemisinin than non-cancerous cells. The dimer configuration has been shown to increase compound stability and reduce general toxicity." @default.