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- B093038f76aab4b8abc3a5f5649b9f3a8 NCIT_P378 "NCI" @default.
- B093038f76aab4b8abc3a5f5649b9f3a8 type Axiom @default.
- B093038f76aab4b8abc3a5f5649b9f3a8 annotatedProperty IAO_0000115 @default.
- B093038f76aab4b8abc3a5f5649b9f3a8 annotatedSource NCIT_C29854 @default.
- B093038f76aab4b8abc3a5f5649b9f3a8 annotatedTarget "The active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties. Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX-1 and-2)-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. This agent may possess chemopreventive activity against colorectal tumors through a mechanism that involves the induction of apoptosis. The sulfide metabolite is excreted in the bile and reabsorbed from the intestine, thereby helping to maintain constant blood levels and reduce gastrointestinal side effects. (NCI04)" @default.