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- B09c7bd2bd5b1b7ac87ea9e70cc00300c NCIT_P378 "NCI" @default.
- B09c7bd2bd5b1b7ac87ea9e70cc00300c type Axiom @default.
- B09c7bd2bd5b1b7ac87ea9e70cc00300c annotatedProperty IAO_0000115 @default.
- B09c7bd2bd5b1b7ac87ea9e70cc00300c annotatedSource NCIT_C2415 @default.
- B09c7bd2bd5b1b7ac87ea9e70cc00300c annotatedTarget "The potassium salt of oxonate, an enzyme inhibitor that modulates 5- fluorouracil (5-FU) toxicity. Potassium oxonate inhibits orotate phosphoribosyltransferase, which catalyzes the conversion of 5-FU to its active or phosphorylated form, FUMP. Upon oral administration, Oxonate is selectively distributed to the intracellular sites of tissues lining the small intestines, producing localized inhibitory effects within the gastrointestinal tract. As a result, 5-FU associated gastrointestinal toxic effects are reduced and the incidence of diarrhea or mucositis is decreased in 5-FU related therapy." @default.