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- B09dcdb8795a045fab0a16f04b3445503 NCIT_P378 "NCI" @default.
- B09dcdb8795a045fab0a16f04b3445503 type Axiom @default.
- B09dcdb8795a045fab0a16f04b3445503 annotatedProperty IAO_0000115 @default.
- B09dcdb8795a045fab0a16f04b3445503 annotatedSource NCIT_C66215 @default.
- B09dcdb8795a045fab0a16f04b3445503 annotatedTarget "The sodium salt form of mycophenolic acid (MPA), with immunosuppressing activity. In vivo, the active molecule MPA reversibly inhibits inosine monophosphate dehydrogenase (IMPDH) which is needed for guanine monophosphate synthesis and stops the proliferation of B and T lymphocytes. Relative to other cell types, lypmocytes are highly dependent on salvage and de novo synthesis of guanine nucleotides, thus making these cells prone to MPA cytotoxicity." @default.