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- B0a47b1527f996542b65d0487430e24f4 NCIT_P378 "NCI" @default.
- B0a47b1527f996542b65d0487430e24f4 type Axiom @default.
- B0a47b1527f996542b65d0487430e24f4 annotatedProperty IAO_0000115 @default.
- B0a47b1527f996542b65d0487430e24f4 annotatedSource NCIT_C486 @default.
- B0a47b1527f996542b65d0487430e24f4 annotatedTarget "A semisynthetic estrogen. Ethinyl estradiol binds to the estrogen receptor complex and enters the nucleus, activating DNA transcription of genes involved in estrogenic cellular responses. This agent also inhibits 5-alpha reductase in epididymal tissue, which lowers testosterone levels and may delay progression of prostatic cancer. In addition to its antineoplastic effects, ethinyl estradiol protects against osteoporosis. In animal models, short-term therapy with this agent has been shown to provide long-term protection against breast cancer, mimicking the antitumor effects of pregnancy. (NCI04)" @default.