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- B0a86a45dfd4fc1beb5cb971c4eb26c15 NCIT_P378 "NCI" @default.
- B0a86a45dfd4fc1beb5cb971c4eb26c15 type Axiom @default.
- B0a86a45dfd4fc1beb5cb971c4eb26c15 annotatedProperty IAO_0000115 @default.
- B0a86a45dfd4fc1beb5cb971c4eb26c15 annotatedSource NCIT_C47662 @default.
- B0a86a45dfd4fc1beb5cb971c4eb26c15 annotatedTarget "The sodium salt of pentobarbital, a short-acting barbituric acid derivative with central nervous system (CNS) depressant property. Pentobarbital sodium binds to the gamma-aminobutyric acid (GABA)-A subtype receptor, resulting in modulation of chloride transport through receptor channels and potentiation of GABA-induced increases in chloride conductance. This enhances postsynaptic responses to the inhibitory actions of GABA and causes CNS depression. In addition, this agent inhibits glutamate induced nerve depolarization and depresses voltage-activated calcium currents." @default.