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- B0aec68d66e91dccceef1eb812139cc0e NCIT_P378 "NCI" @default.
- B0aec68d66e91dccceef1eb812139cc0e type Axiom @default.
- B0aec68d66e91dccceef1eb812139cc0e annotatedProperty IAO_0000115 @default.
- B0aec68d66e91dccceef1eb812139cc0e annotatedSource NCIT_C29027 @default.
- B0aec68d66e91dccceef1eb812139cc0e annotatedTarget "A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism." @default.