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- B0bbbc39a487da1a9e890e0563f147bad NCIT_P378 "NCI" @default.
- B0bbbc39a487da1a9e890e0563f147bad type Axiom @default.
- B0bbbc39a487da1a9e890e0563f147bad annotatedProperty IAO_0000115 @default.
- B0bbbc39a487da1a9e890e0563f147bad annotatedSource NCIT_C401 @default.
- B0bbbc39a487da1a9e890e0563f147bad annotatedTarget "A phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. (NCI04)" @default.