Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B0c0153ac56cc72f72b4a90dce1365e0f> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B0c0153ac56cc72f72b4a90dce1365e0f NCIT_P378 "BIOCARTA" @default.
- B0c0153ac56cc72f72b4a90dce1365e0f type Axiom @default.
- B0c0153ac56cc72f72b4a90dce1365e0f annotatedProperty NCIT_P325 @default.
- B0c0153ac56cc72f72b4a90dce1365e0f annotatedSource NCIT_C38999 @default.
- B0c0153ac56cc72f72b4a90dce1365e0f annotatedTarget "BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1 to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with activity substantially greater than individual BRCA1 or BARD1 subunits. The BRCA1 tumor suppressor forms a heterodimer with the BARD1 protein, and the resulting complex functions as an E3 ubiquitin ligase that catalyzes the synthesis of polyubiquitin chains. UbcH5c and UbcH7 also interact with the BRCA1/BARD1 complex with similar affinity (not shown on this figure). Although the in vivo substrate(s) is not yet known, BRCA1 has been observed to undergo autoubiquitination and is capable of monoubiquitinating histones 2A and 2AX in vitro. (This definition may be outdated - see the DesignNote.)" @default.