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- B0c1e082c92c7b1a891a121179c8599bd NCIT_P378 "NCI" @default.
- B0c1e082c92c7b1a891a121179c8599bd type Axiom @default.
- B0c1e082c92c7b1a891a121179c8599bd annotatedProperty IAO_0000115 @default.
- B0c1e082c92c7b1a891a121179c8599bd annotatedSource NCIT_C18017 @default.
- B0c1e082c92c7b1a891a121179c8599bd annotatedTarget "The T-cell antigen receptors consist of a heterodimer of integral membrane glycoproteins. Two distinct receptors exist, alpha/beta and gamma/delta. Alpha/beta receptors are found on helper and cytotoxic T-cells and are specific for antigenic peptides presented in association with MHC gene products. Gamma/delta receptors, found in association with CD3, directly recognize proteins and non-proteinacious phospho-ligands. Alpha/beta and gamma/delta are non-covalently associated with CD3-gamma, -delta, -epsilon, and -zeta proteins, forming the TCR-CD3 complex, which activate MAPKs and JNK1 through the CD3 antigens, the adaptor protein LAT, and tyrosine kinases LCK and ZAP70. The genes for T-cell receptor subunits are encoded by distinct gene elements that are assembled by somatic rearrangement during T-cell development. Translocations and inversions of these loci are observed in human T-cell leukemias and lymphomas." @default.