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- B0c3cb6a7f59ce6ab2438939d12d2cb31 NCIT_P378 "NCI" @default.
- B0c3cb6a7f59ce6ab2438939d12d2cb31 type Axiom @default.
- B0c3cb6a7f59ce6ab2438939d12d2cb31 annotatedProperty IAO_0000115 @default.
- B0c3cb6a7f59ce6ab2438939d12d2cb31 annotatedSource NCIT_C1413 @default.
- B0c3cb6a7f59ce6ab2438939d12d2cb31 annotatedTarget "A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery." @default.