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- B0c453bcef2e549fef79a8a41c33a1c3f NCIT_P378 "NCI" @default.
- B0c453bcef2e549fef79a8a41c33a1c3f type Axiom @default.
- B0c453bcef2e549fef79a8a41c33a1c3f annotatedProperty IAO_0000115 @default.
- B0c453bcef2e549fef79a8a41c33a1c3f annotatedSource NCIT_C20573 @default.
- B0c453bcef2e549fef79a8a41c33a1c3f annotatedTarget "Human HMGA Family Genes encode HMGA proteins that participate in many nuclear processes ranging from chromosome and chromatin mechanics to transcription factors that regulate gene expression. Hence, they influence diverse biological processes including cell growth, proliferation, differentiation and death. HMGA proteins contain three AT-hooks that bind to minor groove AT-rich stretches. HMGA proto-oncogenes promote tumor progression and metastasis when overexpressed. High constitutive HMGA expression is consistently observed in cancers, with increasing concentrations being correlated with increasing malignancy. (NCI)" @default.