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- B0c54bb300df0f86dba62d698d9dd7573 NCIT_P378 "NCI" @default.
- B0c54bb300df0f86dba62d698d9dd7573 type Axiom @default.
- B0c54bb300df0f86dba62d698d9dd7573 annotatedProperty IAO_0000115 @default.
- B0c54bb300df0f86dba62d698d9dd7573 annotatedSource NCIT_C179276 @default.
- B0c54bb300df0f86dba62d698d9dd7573 annotatedTarget "A human monoclonal antibody with a masked antibody binding site directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon intravenous administration and the activation of the antibody binding site in the tumor microenvironment (TME), muzastotug targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells, thereby killing cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system." @default.