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- B0c7dd87629ac58a5bc570c59d7871a55 NCIT_P378 "NCI" @default.
- B0c7dd87629ac58a5bc570c59d7871a55 type Axiom @default.
- B0c7dd87629ac58a5bc570c59d7871a55 annotatedProperty IAO_0000115 @default.
- B0c7dd87629ac58a5bc570c59d7871a55 annotatedSource NCIT_C170744 @default.
- B0c7dd87629ac58a5bc570c59d7871a55 annotatedTarget "An inhibitor of the fibroblast growth factor receptor (FGFR) type 2 (FGFR2), with potential antineoplastic and anti-angiogenic activities. Upon administration, alofanib targets, allosterically binds to the extracellular domain of FGFR2 and inhibits the activity of FGFR2, which may result in the inhibition of basic FGF (bFGF)/FGFR2-related signal transduction pathways. This inhibits FGF-induced endothelial cell proliferation and migration, and inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival." @default.