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- B0c8f9cb9b61a96bdd9c653a2f370f834 NCIT_P378 "NCI" @default.
- B0c8f9cb9b61a96bdd9c653a2f370f834 type Axiom @default.
- B0c8f9cb9b61a96bdd9c653a2f370f834 annotatedProperty IAO_0000115 @default.
- B0c8f9cb9b61a96bdd9c653a2f370f834 annotatedSource NCIT_C47735 @default.
- B0c8f9cb9b61a96bdd9c653a2f370f834 annotatedTarget "A broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties. Sulfadoxine competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of parasitic folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death." @default.