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- B0cc285bcfe4561e00689947de7199907 NCIT_P378 "NCI" @default.
- B0cc285bcfe4561e00689947de7199907 type Axiom @default.
- B0cc285bcfe4561e00689947de7199907 annotatedProperty IAO_0000115 @default.
- B0cc285bcfe4561e00689947de7199907 annotatedSource NCIT_C189061 @default.
- B0cc285bcfe4561e00689947de7199907 annotatedTarget "A monospecific hexamer-forming antibody, based on the HexaBody technology platform, directed against the cell surface antigen CD27, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CD27 monoclonal antibody GEN1053/BNT313 targets and binds to CD27 expressed on a variety of immune cell types, including most T-lymphocytes, and forming a hexamer upon binding. This induces CD27-mediated signaling, and enhances CD27-mediated responses, including the expansion of antigen-activated T-cells and natural killer (NK) cells. This restores immune function and leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD27, a co-stimulatory molecule and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes, memory B-cells and NK cells. It plays an important role in NK cell-mediated cytolytic activity and T- and B-lymphocyte proliferation and activation." @default.