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- B0ce62d9ac7291e98d5cce5d6690833f5 NCIT_P378 "NCI" @default.
- B0ce62d9ac7291e98d5cce5d6690833f5 type Axiom @default.
- B0ce62d9ac7291e98d5cce5d6690833f5 annotatedProperty IAO_0000115 @default.
- B0ce62d9ac7291e98d5cce5d6690833f5 annotatedSource NCIT_C66945 @default.
- B0ce62d9ac7291e98d5cce5d6690833f5 annotatedTarget "The hydrochloride salt of a bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition." @default.