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- B0dd69e1682bbea626a9b90b90e071b6c NCIT_P378 "NCI" @default.
- B0dd69e1682bbea626a9b90b90e071b6c type Axiom @default.
- B0dd69e1682bbea626a9b90b90e071b6c annotatedProperty IAO_0000115 @default.
- B0dd69e1682bbea626a9b90b90e071b6c annotatedSource NCIT_C567 @default.
- B0dd69e1682bbea626a9b90b90e071b6c annotatedTarget "An immunoglobulin isotype (subclass). This isotype has the unique ability to bind with high affinity to IgE receptors (FceRI) on mast cells and basophils and induce degranulation and cytokine production by these cells when they are crosslinked by antigen. In addition to a central role in atopy and allergic responses, it has been speculated that IgE-mediated mast cell degranulation, by its release of mediators that increase vascular permeability, has an important role in the initiation of immune response in general." @default.