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- B0e17ef63c6b8fa75154cef6fb4f9e58e NCIT_P378 "NCI" @default.
- B0e17ef63c6b8fa75154cef6fb4f9e58e type Axiom @default.
- B0e17ef63c6b8fa75154cef6fb4f9e58e annotatedProperty IAO_0000115 @default.
- B0e17ef63c6b8fa75154cef6fb4f9e58e annotatedSource NCIT_C853 @default.
- B0e17ef63c6b8fa75154cef6fb4f9e58e annotatedTarget "A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04)" @default.