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- B0e25663e5f0a4eb96f83d35aa4c9bd0e NCIT_P378 "NCI" @default.
- B0e25663e5f0a4eb96f83d35aa4c9bd0e type Axiom @default.
- B0e25663e5f0a4eb96f83d35aa4c9bd0e annotatedProperty IAO_0000115 @default.
- B0e25663e5f0a4eb96f83d35aa4c9bd0e annotatedSource NCIT_C189804 @default.
- B0e25663e5f0a4eb96f83d35aa4c9bd0e annotatedTarget "A bivalent booster vaccine consisting of elasomeran, a lipid nanoparticle (LNP) encapsulating a messenger RNA (mRNA) encoding the prefusion stabilized spike (S) protein of the SARS-CoV-2 Wuhan-Hu-1 strain (original), and davesomeran, a LNP encapsulating mRNA encoding the prefusion stabilized S-protein of the SARS-CoV-2 Omicron variant lineages BA.4 and BA.5 (Omicron BA.4/BA.5), with potential immunizing activity against SARS-CoV-2. Upon administration of elasomeran/davesomeran, the LNPs bind to the plasma membrane of cells and release the mRNA into the cells. The mRNA is then translated by ribosomes to produce the SARS-CoV-2 S protein. This may activate both humoral and cellular immune responses which may result in protection against SARS-CoV-2 infection." @default.