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- B0e41f0de681ca06ab9e51411558893df NCIT_P378 "NCI" @default.
- B0e41f0de681ca06ab9e51411558893df type Axiom @default.
- B0e41f0de681ca06ab9e51411558893df annotatedProperty IAO_0000115 @default.
- B0e41f0de681ca06ab9e51411558893df annotatedSource NCIT_C96795 @default.
- B0e41f0de681ca06ab9e51411558893df annotatedTarget "An orally available inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, ABT-767 selectively binds to PARP 1 and 2, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of DNA strand breaks and promotes genomic instability eventually leading to apoptosis. ABT-767 may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand DNA (ssDNA) breaks." @default.