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- B0e53e946b21bfd2599a90786453d2b03 NCIT_P378 "NCI" @default.
- B0e53e946b21bfd2599a90786453d2b03 type Axiom @default.
- B0e53e946b21bfd2599a90786453d2b03 annotatedProperty IAO_0000115 @default.
- B0e53e946b21bfd2599a90786453d2b03 annotatedSource NCIT_C28871 @default.
- B0e53e946b21bfd2599a90786453d2b03 annotatedTarget "The fumarate salt of a synthetic phenoxy-2-propanol-derived cardioselective beta-1 adrenergic receptor antagonist with antihypertensive and potential cardioprotective activities. Devoid of intrinsic sympathomimetic activity, bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, decreasing cardiac contractility and rate, reducing cardiac output, and lowering blood pressure. In addition, this agent may exhibit antihypertensive activity through the inhibition of renin secretion by juxtaglomerular epithelioid (JGE) cells in the kidney, thus inhibiting activation of the renin-angiotensin system (RAS). Bisoprolol has been shown to be cardioprotective in animal models." @default.