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- B0e8e124918352932463f01965052777a NCIT_P378 "NCI" @default.
- B0e8e124918352932463f01965052777a type Axiom @default.
- B0e8e124918352932463f01965052777a annotatedProperty IAO_0000115 @default.
- B0e8e124918352932463f01965052777a annotatedSource NCIT_C161864 @default.
- B0e8e124918352932463f01965052777a annotatedTarget "An agonistic humanized IgG1 monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory activity. Upon administration, revdofilimab selectively binds to and activates OX40. This may induce the proliferation of memory and effector T-lymphocytes and inhibit the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME). OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation and differentiation." @default.