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- B0f544a5811ca9d897c0afa2bf917e037 NCIT_P378 "NCI" @default.
- B0f544a5811ca9d897c0afa2bf917e037 type Axiom @default.
- B0f544a5811ca9d897c0afa2bf917e037 annotatedProperty IAO_0000115 @default.
- B0f544a5811ca9d897c0afa2bf917e037 annotatedSource NCIT_C182003 @default.
- B0f544a5811ca9d897c0afa2bf917e037 annotatedTarget "An orally bioavailable and selective inhibitor of DNA polymerase (pol) theta, with potential chemosensitizing and antineoplastic activities. Upon oral administration, Pol theta inhibitor ART4215 targets, binds to and inhibits the activity of pol theta. This prevents pol theta-mediated repair of damaged DNA and may have a synergistic effect if administered in combination with agents that cause DNA damage. Pol theta plays a key role in DNA synthesis and repair." @default.