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- B0f826e67f5985db3ac199e03f4ffa8f9 NCIT_P378 "NCI" @default.
- B0f826e67f5985db3ac199e03f4ffa8f9 type Axiom @default.
- B0f826e67f5985db3ac199e03f4ffa8f9 annotatedProperty IAO_0000115 @default.
- B0f826e67f5985db3ac199e03f4ffa8f9 annotatedSource NCIT_C340 @default.
- B0f826e67f5985db3ac199e03f4ffa8f9 annotatedTarget "A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. (NCI04)" @default.