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- B0fae8b4167144c29e3ba49a3eebbfcc0 NCIT_P378 "NCI" @default.
- B0fae8b4167144c29e3ba49a3eebbfcc0 type Axiom @default.
- B0fae8b4167144c29e3ba49a3eebbfcc0 annotatedProperty IAO_0000115 @default.
- B0fae8b4167144c29e3ba49a3eebbfcc0 annotatedSource NCIT_C1336 @default.
- B0fae8b4167144c29e3ba49a3eebbfcc0 annotatedTarget "A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)" @default.