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- B0fcc90eb9b13a5f95b98775dd3af94b5 NCIT_P378 "NCI" @default.
- B0fcc90eb9b13a5f95b98775dd3af94b5 type Axiom @default.
- B0fcc90eb9b13a5f95b98775dd3af94b5 annotatedProperty IAO_0000115 @default.
- B0fcc90eb9b13a5f95b98775dd3af94b5 annotatedSource NCIT_C156777 @default.
- B0fcc90eb9b13a5f95b98775dd3af94b5 annotatedTarget "An orally available inhibitor of dihydroorotate dehydrogenase (DHODH), with potential antineoplastic activity. Upon administration, farudodstat specifically targets, binds to and prevents the activation of DHODH, thereby preventing the fourth enzymatic step in de novo pyrimidine synthesis. This prevents uridine monophosphate (UMP) formation, DNA synthesis, cell division and cellular proliferation, causes reactive oxygen species (ROS) formation, enables differentiation and induces apoptosis in susceptible tumor cells. DHODH, a mitochondrial enzyme, catalyzes the conversion of dihydroorotate (DHO) to orotate in the endogenous synthesis of UMP." @default.