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- B100393e2f516f2c5d616b081f69cff0e NCIT_P378 "NCI" @default.
- B100393e2f516f2c5d616b081f69cff0e type Axiom @default.
- B100393e2f516f2c5d616b081f69cff0e annotatedProperty IAO_0000115 @default.
- B100393e2f516f2c5d616b081f69cff0e annotatedSource NCIT_C1004 @default.
- B100393e2f516f2c5d616b081f69cff0e annotatedTarget "A piperidinedione antineoplaston with potential antineoplastic activity. Antineoplaston A10 was originally isolated from human urine but is now synthetically derived. This agent intercalates into DNA, resulting in cell cycle arrest in G1 phase, reduction of mitosis, and decreased protein synthesis. Antineoplaston A10 may also inhibit ras-oncogene expression and activate tumor suppressor gene p53, leading to cell differentiation and apoptosis. (NCI04)" @default.