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- B10231632687d8454528f3b385c00686d NCIT_P378 "NCI" @default.
- B10231632687d8454528f3b385c00686d type Axiom @default.
- B10231632687d8454528f3b385c00686d annotatedProperty IAO_0000115 @default.
- B10231632687d8454528f3b385c00686d annotatedSource NCIT_C96735 @default.
- B10231632687d8454528f3b385c00686d annotatedTarget "A recombinant vaccine containing a genetically detoxified adenylate cyclase toxin (CyaA) of Bordetella pertussis coupled, through its catalytic site, to the melanoma tyrosinase A2 epitope YMDGTMSQV, with potential antineoplastic activity. Via the toxin moiety, the recombinant B. pertussis adenylate cyclase toxin-tyrosinase A2 epitope specifically binds to the alphaMbeta2 integrin (CD11b/CD18) located on CD11b-positive antigen-presenting cells (APC). Upon processing and presentation of the melanoma-specific epitope by MHC class I molecules to the surface of these APCs, a specific cytotoxic T-cell (CTL) response against tumor cells expressing tyrosinase may be initiated, resulting in decreased tumor growth and cell lysis." @default.