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- B104fc7772d2ecb48b8c459ad45a508ee NCIT_P378 "NCI" @default.
- B104fc7772d2ecb48b8c459ad45a508ee type Axiom @default.
- B104fc7772d2ecb48b8c459ad45a508ee annotatedProperty IAO_0000115 @default.
- B104fc7772d2ecb48b8c459ad45a508ee annotatedSource NCIT_C37274 @default.
- B104fc7772d2ecb48b8c459ad45a508ee annotatedTarget "Human Interferon Alpha Receptor Complex (Type II Cytokine Family Receptor) is a ubiquitous type I membrane protein heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI)" @default.