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- B10a353a4fc9c475e6ebcbb1cd5569b49 NCIT_P378 "NCI" @default.
- B10a353a4fc9c475e6ebcbb1cd5569b49 type Axiom @default.
- B10a353a4fc9c475e6ebcbb1cd5569b49 annotatedProperty IAO_0000115 @default.
- B10a353a4fc9c475e6ebcbb1cd5569b49 annotatedSource NCIT_C49061 @default.
- B10a353a4fc9c475e6ebcbb1cd5569b49 annotatedTarget "A small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway." @default.