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- B10eb6fb482d58cae4778926ef4e99b1a NCIT_P378 "NCI" @default.
- B10eb6fb482d58cae4778926ef4e99b1a type Axiom @default.
- B10eb6fb482d58cae4778926ef4e99b1a annotatedProperty IAO_0000115 @default.
- B10eb6fb482d58cae4778926ef4e99b1a annotatedSource NCIT_C158504 @default.
- B10eb6fb482d58cae4778926ef4e99b1a annotatedTarget "A human bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFvs): one directed again the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and another directed against the CD3 antigen expressed on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, linvoseltamab binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, leading to CTL-mediated killing of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival." @default.