Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B10f2f0e8e20b51daf82a0b2610de2469> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B10f2f0e8e20b51daf82a0b2610de2469 NCIT_P378 "NCI" @default.
- B10f2f0e8e20b51daf82a0b2610de2469 type Axiom @default.
- B10f2f0e8e20b51daf82a0b2610de2469 annotatedProperty IAO_0000115 @default.
- B10f2f0e8e20b51daf82a0b2610de2469 annotatedSource NCIT_C61897 @default.
- B10f2f0e8e20b51daf82a0b2610de2469 annotatedTarget "The sulfate salt form of polymyxin B1, a polypeptide obtained from Bacillus polymyxa strains with antimicrobial activity. Polymyxin B1 exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B1 dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death." @default.